abstract：:Experiments were conducted on the effects of various dose levels of benzo [a]pyrene (BP) on nuclear size in mouse interfollicular epidermis over a 3-day period. Topical application of BP was made with or without croton oil (CO) (0.1 or 0.5%) in the vehicles acetone, toluene and methyl ethyl ketone (MEK). Nuclear size ...

journal_title：Chemico-biological interactions

authors： Ingram AJ

更新日期：1979-06-01 00:00:00

abstract：:Treatment of rats with two different doses of CCl4 (respectively 2.5 and 0.5 ml/kg body wt. intragastrically) is followed by a rapid increase in the cAMP content of the liver. With 0.5 ml of CCl4, the increase occurs as early as 30 min after poisoning, namely about 4-5 h before the onset of triglyceride accumulation i...

journal_title：Chemico-biological interactions

authors： Paradisi L,Dianzani MU

更新日期：1979-06-01 00:00:00

abstract：:American oysters (Crassostrea virginica) were exposed to 0.1 ppm cadmium for 0--15 days in a flowing seawater system and then placed into clean flowing seawater for 24 h prior to sacrifice. Whole oysters were homogenized and a cadmium-binding protein isolated and purified by a process of centrifugation, heat-treatment...

journal_title：Chemico-biological interactions

authors： Ridlington JW,Fowler BA

更新日期：1979-05-01 00:00:00

abstract：:The administration of cephaloridine to rats caused a decrease in the excretion of acid phosphatase into the urine. The antibiotic itself had no effect on urinary acid phosphatase and inhibitors or proteolytic enzymes were not present in the urine from treated rats. Cephaloridine may therefore be stabilizing the lysoso...

journal_title：Chemico-biological interactions

authors： Ngaha EO,Fry M,Plummer DT

更新日期：1979-02-01 00:00:00

abstract：:The relative toxicities of particulate beryllium phosphate, soluble beryllium sulphate and a beryllium sulphosalicylate complex to a rat liver parencymal derived cell line have been examined in culture. Due to the propensity of beryllium salts to form beryllium phosphate in solution the incubation medium used was free...

journal_title：Chemico-biological interactions

authors： Skilleter DN,Paine AJ

更新日期：1979-01-01 00:00:00

abstract：:Two diol epoxides of benzo(a)pyrene (BP), and benzo(a)pyrene 4,5-oxide, have been used to make adducts in the homopolymers polyribocytidylic acid, (rC); polyriboadenylic acid (rA), polydeoxycytidylic acid (dC) and polydeoxyadenylic acid (dA). With appropriate oligomers as primers these modified and unmodified polynucl...

journal_title：Chemico-biological interactions

authors： Yamaura I,Marquardt H,Cavalieri LF

更新日期：1978-12-01 00:00:00

abstract：:The general features of the reduction of nitroblue tetrazolium chloride (NBT) by NADH and phenazine methosulphate (PMS) have been studied under aerobic and anaerobic conditions. Under aerobic condition the reduction appears to be mediated through the intermediate formation of the superoxide anion radical O2-.; this re...

journal_title：Chemico-biological interactions

authors： Ponti V,Dianzani MU,Cheeseman K,Slater TF

更新日期：1978-12-01 00:00:00

abstract：:DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine (OMPI) a sulfhydryl metabolite of levamisole, unlike the parent compound, is shown to interfere with the morphological and functional integrity of microtubules in cultured cells at high concentrations (1.6-10(-4) M). Lower concentrations do not affect the cell morphol...

journal_title：Chemico-biological interactions

authors： De Brabander M,Aerts F,Geuens G,van Ginckel R,van de Veire R,van Belle H

更新日期：1978-10-01 00:00:00

abstract：:Microsomal epoxide hydrase (EH) and 176 000 g supernatant fraction glutathione-S-transferase (GSH-S-T) activities were determined with styrene oxide as substrate in rat testes during postnatal development. The development of these enzymes was also followed in liver for comparison. Testes of 6-day-old rats had high GSH...

journal_title：Chemico-biological interactions

authors： Mukhtar H,Lee IP,Foureman GL,Bend JR

更新日期：1978-09-01 00:00:00

abstract：:In order to assess the role played respectively by the pseudothiourea group and the alkylic chain in the inhibition of protein synthesis and tumour growth caused by compound AHR-1911, a series of eight related substances were studied. The blockade of protein synthesis on liver and Walker carcinoma ribosomes and on sus...

journal_title：Chemico-biological interactions

authors： Carmona A,Gonzalez-Cadavid NF

更新日期：1978-09-01 00:00:00

abstract：:The effects of various factors, including population doubling number, percent of confluence, serum concentration and storage in liquid nitrogen on the binding of several polycyclic aromatic hydrocarbons to human and hamster embryo cells were studied. The binding of 7,12-dimethylbenz[a]-anthracene (DMBA) to hamster emb...

journal_title：Chemico-biological interactions

authors： Raineri R,Poiley JA,Hillesund T,Pienta RJ

更新日期：1978-09-01 00:00:00

abstract：:Penicillamine (I) and certain related compounds are known to reduce the skin tensile strength (sts) of rat dorsal skin when they are given in the diet. This effect seems significant to studies of the biochemistry of collagen and of diseases of collagen, perhaps including the arthritides. The reduction of sts appears t...

journal_title：Chemico-biological interactions

authors： Hanley WS,Snyder ME,Field L,Gallo AA

更新日期：1978-06-01 00:00:00

abstract：:A microspectrophotometric method for assaying cytochrome P-450 in fresh 24 micrometer unfixed cryostat sections of rat liver has been developed. When used to assay this cytochrome in sections of microsomal preparations it has yielded results equivalent to those obtained by the conventional spectrophotometric assay of ...

journal_title：Chemico-biological interactions

authors： Gooding PE,Chayen J,Sawyer B,Slater TF

更新日期：1978-03-01 00:00:00

abstract：:The 2 pH dependent peaks formed in the Soret region by the treatment of reduced hepatic microsomes or purified cytochrome P-448 with ethyl isocyanide do not exhibit identical dependence on ethyl isocyanide concentration. This behavior and other facts regarding double Soret spectra can be explained by a simple expostul...

journal_title：Chemico-biological interactions

authors： Dahl AR,Hodgson E

更新日期：1978-02-01 00:00:00

abstract：:Pretreatment of secondary cultures of Syrian hamster embryo cells with 7,8-benzoflavone (7,8-BF) inhibited both the metabolism of 7,12-dimethylbenz[alpha] anthracene (DMBA) and the formation of DMBA-DNA adducts. The DMBA-deoxyribonucleoside adducts from 7,8-BF-treated cultures had the same elution profiles on Sephadex...

journal_title：Chemico-biological interactions

authors： Baird WM,Diamond L

更新日期：1978-02-01 00:00:00

abstract：:Potent inhibition of human prostatic carcinoma tissue acid phosphatase by N,N-d-di-2-chloroethylaminophenol (AMOH) and N,N-p-di-2-chloroethylaminophenyl phosphate (AMPh) is described. Certain other difunctional nitrogen mustards were also inhibitory but N,N-p-di-2hydroxyethylaminophenol, the non-alkylating fully hydro...

journal_title：Chemico-biological interactions

authors： Workman P

更新日期：1978-01-01 00:00:00

abstract：:Effects of hepatocarcinogens dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) on the sedimentation pattern of rat liver DNA in alkaline sucrose gradients were studied with regard to time and dose dependency. Both DMN (10 mg/kg body weight) and den (13.4 or 134 mg/kg) induced appreciably decreased DNA sedimentati...

journal_title：Chemico-biological interactions

authors： Den Engelse L,Philippus EJ

更新日期：1977-10-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, whil...

journal_title：Chemico-biological interactions

authors： Kasschau MR,Elder J,Meyn RE

更新日期：1977-08-01 00:00:00

abstract：:4-Methylcyclophosphamide, an analogue of the antitumour agent cyclophosphamide, exists in cis and trans forms, each of which comprises a pair of optical isomers. The extents of metabolism by rat liver microsomes during 20 min were compared for the four steroisomers incubated separately, and for the racemic cis and tra...

journal_title：Chemico-biological interactions

authors： Farmer PB,Jarman M,Facchinetti T,Pankiewicz K,Stec WJ

更新日期：1977-07-01 00:00:00

abstract：:The effects of benzoflavones on skin tumor initiation by polycyclic hydrocarbons and epidermal aryl hydrocarbon hydroxylase were investigated. 7,8-Benzoflavone (7,8-BF) was found to be a potent inhibitor of the inhibition of skin tumors by 3-methylcholanthrene (MC) as well as 7,12-dimethylbenz(a)anthracene (DMBA). 5,6...

journal_title：Chemico-biological interactions

authors： Slaga TJ,Thompson S,Berry DL,Digiovanni J,Juchau MR,Viaje A

更新日期：1977-06-01 00:00:00

abstract：:The intercalating dye ethidium bromide (EB), inhibits excision of pyrimidine dimers from UV-irradiated excision-proficient Escherichia coli B/r hcr+ cells. Inhibition is total at a 2.5 - 10(-4) M concentration 120 min after irradiation with a dose of 750 erg/mm2. The viability of irradiated cells diminishes in proport...

journal_title：Chemico-biological interactions

authors： Masek F

更新日期：1977-05-01 00:00:00

abstract：:The effects of 3-methylcholanthrene (MCA), 5,6-benzoflavone (betaNF), 7,8-benzoflavone (alphaNF) and pregnenolone 16alpha-carbonitrile (PCN) upon aryl hydrocarbon hydroxylase (AHH) were determined in primary mammary gland epithelial cell cultures prepared from the C3Hf-/Ki mouse. MCA elevated AHH activity by 3--4 fold...

journal_title：Chemico-biological interactions

authors： Chuang AH,Howard EF,Bresnick E

更新日期：1977-04-01 00:00:00

abstract：:The reaction of cytosine and 5-hydroxymethyl-cytosine (OHMeCyt) with a variety of monofunctional alkylating agents has been investigated to evaluate further the possible role of cytosine alkylation in mutagenesis and the possibility that the immunity of T-even phages to mutation by methyl methanesulphonate (MMS) was d...

journal_title：Chemico-biological interactions

authors： Smith BJ

更新日期：1977-03-01 00:00:00

abstract：:A chromatographic procedure for improved separation of deoxyribonucleosides and methylated deoxyribonucleosides is described. DNA was isolated from liver and small intestine of rats treated with [14C]dimethylnitrosamine ([14C]DMN) or N-[3H]methyl-N-nitrosourea ([3H]MNU), and the purified DNA was hydrolyzed enzymatical...

journal_title：Chemico-biological interactions

authors： Daoud AH,Irving CC

更新日期：1977-02-01 00:00:00

abstract：:The in vitro metabolism of p-nitroanisole, aminopyrine, and aniline by rat liver microsomal monoxygenases were studied in the presence of different polychlorinated biphenyl (PCB) mixtures and some related hydroxybiphenyls. The tested PCB mixtures contained preferably dichloro- (di-CB), tetrachloro- (tetra-CB), or hexa...

journal_title：Chemico-biological interactions

authors： Schmoldt A,Herzberg W,Benthe HF

更新日期：1977-02-01 00:00:00

abstract：:We had previously reported that the carcinogen, beta-propiolactone (BPL) reacted in vitro with histones in whole mouse skin chromatin and that among the histone classes BPL was preferentially bound to the lysine-rich histones H1 and H1 degrees. In order to determine if in vitro reaction of BPL with calf thymus histone...

journal_title：Chemico-biological interactions

authors： Segal A,Garte SJ

更新日期：1976-12-01 00:00:00

abstract：:The interaction of the potent tumor-promoting agent phorbol myristate acetate (PMA) with purified rat liver plasma membranes suspended in phosphate-buffered saline (PBS), pH 7.4, was studied by fluorescence spectrophotometry. Exposure of membranes to PMA caused up to 21% decrease of the native membrane emission, i.e. ...

journal_title：Chemico-biological interactions

authors： van Duuren BL,Banerjee S,Witz G

更新日期：1976-11-01 00:00:00

abstract：:Administration of hepatotoxic doses of allyl alcohol and N-hydroxy-2-acetylaminofluorene (N-OH-AAF) TO adult male rats produced periportal necrosis and functional derangement of the hepatic endoplasmic reticulum within 24 h. The rates of N-demethylation of ethylmorphine and p-hydroxylation of aniline were decreased 6 ...

journal_title：Chemico-biological interactions

authors： Thorgeirsson SS,Mitchell JR,Sasame HA,Potter WZ

更新日期：1976-10-02 00:00:00

abstract：:It has been suggested that the binding of iron(III) by phosvitin involves the phosphoric radicals of phosphorylserine residues, many of which are arranged in rows of several consecutive phosphoamino acids. In this paper we present evident that, unlike free phosphorylserine which does not interact with Fe(III), polypho...

journal_title：Chemico-biological interactions

authors： Donella A,Pinna LA,Moret V

更新日期：1976-10-02 00:00:00

abstract：:Uptake of Hg2+ into the renal and hepatic metallothioneins of rats is increased by pretreatment with Cd2+. This increased uptake occurs both by displacement of Cd2+ (and of Zn2+) from the presynthesized cadmium-thionein, and by further synthesis of thionein. The former mechanism predominates in the kidney of the male ...

journal_title：Chemico-biological interactions

authors： Webb M,Magos L

更新日期：1976-08-01 00:00:00

abstract：:The biological and physicochemical effects of reacting bacteriophages R17 and T7 with acetoxy-dimethylnitrosamine (ADMN) have been studied. The rate-determining step in the reactions appeared to be the loss of the acetoxy group by hydrolysis, the hydroxymethyl-methylnitrosamine generated decomposing rapidly to give a ...

journal_title：Chemico-biological interactions

authors： Shooter KV,Wiessler M

更新日期：1976-07-01 00:00:00

abstract：:Repair synthesis has been followed in P388F cell DNA following treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) using 5-iodo-deoxyuridine (IUdR) and [3H] thymidine combination. A pattern of repair synthesis was obtained, similar in its timing to the initial and medial stages of single-strand break formation ...

journal_title：Chemico-biological interactions

authors： Nikaido O,Fox BW

更新日期：1976-07-01 00:00:00

abstract：:To determine correlations between the biological action pattern and chemical reactivity of alkylating agents, the rate constants for reactions of 1,3-propane sultone and 1,4-butane sultone with a series of nucleophiles at 37 degrees C have been determined. Previously published data on the mutagenicity of the two sulto...

journal_title：Chemico-biological interactions

authors： Osterman-Golkar S,Wachtmeister CA

更新日期：1976-07-01 00:00:00

abstract：:The degradation in alkali of normal DNA and DNA alkylated with dimethyl sulphate (DMS), N-methyl-N-nitrosourea (MNUA) and N-ethyl-N-nitrosourea (ENUA) has been investigated using analytical ultracentrifugation techniques. For control T7-DNA (w.st. denatured form 12.5 - 10(6) daltons) the rate of degradation at 37 degr...

journal_title：Chemico-biological interactions

authors： Shooter KV

更新日期：1976-05-01 00:00:00

abstract：:Multiple factors contribute to the development of neoplasia. Sometimes a single agency can bring about a tumour if it has many different effects, but at other times a tumour arises more insidiously due to a succession of events [240,241] which by themselves may be innocent. Alterations in the genome of the cell are at...

journal_title：Chemico-biological interactions

authors： Frei JV

更新日期：1976-04-01 00:00:00

abstract：:Previous investigations have shown that the carcinogen vinyl chloride causes base-pair substitution in the bacterium Salmonella typhimurium. The ability of four conceivable metabolites-chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid-to cause base-pair substitution directly in Salmonella...

journal_title：Chemico-biological interactions

authors： Rannug U,Göthe R,Wachtmeister CA

更新日期：1976-03-01 00:00:00

abstract：:7,12-Dimethylbenz(a)anthracene (DMBA) and 7-methoxymethyl-12-methylbenz(a)anthracene (MeO-DMBA) are converted to a number of products during short exposures in aqueous suspension to laboratory illumination. The mixture of products binds to glyceraldehyde-3-phosphate dehydrogenase (GPDH) while inhibiting its activity b...

journal_title：Chemico-biological interactions

authors： Grubbs CJ,Wood JL

更新日期：1976-02-01 00:00:00

abstract：:5-Iodouracil (IUra)-substituted progeny bacteriophage T4td8 were grown under conditions such that, upon CsCl equilibrium isopycnic gradient centrifugation, progeny with density distributions about the median similar to that of unsubstituted phage are obtained. In the absence of light a monotonic relationship exists be...

journal_title：Chemico-biological interactions

authors： Byrd DM,Prusoff WH

更新日期：1976-02-01 00:00:00

abstract：:(1) Subcutaneous or intra-abdominal injections of 8 mg of HgCl2/100 g body weight markedly depressed hepatic fatty acid synthetase activity of chicks at 1 h post-injection. The depression occurred despite the fact that the chicks continued to eat up until the time they were killed. Under these same conditions, the hep...

journal_title：Chemico-biological interactions

authors： Donaldson WE

更新日期：1975-11-01 00:00:00

abstract：:Treatment of rats with the aminonucleoside of puromycin, which increases the incorporation of labelled phenylalanyl-tRNA into polypeptide chains in liver ribosome preparations studied in vitro, did not change the factor-dependent binding of fMet-tRNA f Met to ribosomes nor the peptidyl transferase function of the ribo...

journal_title：Chemico-biological interactions

authors： Innanen VT,Nicholls DM

更新日期：1975-11-01 00:00:00